8/7/2023 0 Comments Lzip atf2![]() Several studies implicate abnormal activation of ATF-2 in growth and progression of mammalian skin tumors. ATF-2 phosphorylation in response to treatment of cells with tumor promoter phorbol ester has been demonstrated. ATF-2 is normally activated in response to signals that converge on stress-activated protein kinases p38 and JNK. Studies in mice indicate a role for ATF-2 in the development of nervous system and the skeleton. The gene atf2 is located at human chromosome 2q32. Additional transcript variants have been identified but their biological validity has not been determined. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro thus, it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The protein forms a homodimer or heterodimer with c-Jun. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. positive regulation of cardiac muscle myoblast proliferationĪctivating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.positive regulation of transcription by RNA polymerase II.negative regulation of epithelial cell proliferation.positive regulation of mitochondrial membrane permeability involved in apoptotic process.regulation of DNA-binding transcription factor activity.positive regulation of neuron apoptotic process.cellular response to DNA damage stimulus.positive regulation of transforming growth factor beta2 production.negative regulation of transcription by RNA polymerase II.positive regulation of DNA-binding transcription factor activity.mitotic intra-S DNA damage checkpoint signaling.regulation of transcription by RNA polymerase II.regulation of transcription, DNA-templated.
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